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Mutagenesis— Tadalafil was not mutagenic within the in vitrobacterial Ames assays or perhaps the ahead mutation take a look at in mouse lymphoma cells. Tadalafil was not clastogenic in the in vitrochromosomal aberration exam in human lymphocytes or even the in vivorat micronucleus assays.No dose adjustment is warranted. The lowered exposure of ta